日本語 
Fujifilm along with HORIBA kind of jointly developed a high-sensitivity inline Raman setup that lets biopharmaceutical folks keep an eye on cell culture and purification activities in real time. What it does is pretty direct it keeps measuring the component concentrations straight inside bioreactors and other process equipment, so there’s less need for that repeated sampling stuff or offline checking, which is kind of time consuming.
And yeah as biopharmaceutical products like antibody drugs, cell therapies, and gene therapies get more complicated, manufacturers feel more pressure to hold the product quality steady, while also pushing for better production efficiency. Even small wiggles in the process settings can mess with the end result, so ‘instant visibility’ is becoming a big deal across the industry, more and more.
The new system combines HORIBA’s Raman spectroscopy technology with Fujifilm’s single-use optical probe and proprietary measurement algorithms. This setup enables high-precision monitoring of cell culture media, target substances, and impurities throughout production.
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In antibody drug purification processes, the system demonstrated about a 10% improvement in yield compared with conventional UV-Vis-based process control methods. Unlike traditional approaches that mainly track total protein levels, the Raman-based system can distinguish antibodies from impurities more accurately, helping manufacturers identify the optimal collection point.
Beyond purification, the technology can also monitor amino acids and other components during cell culture, helping manufacturers better control production conditions and reduce batch-to-batch variation. Fujifilm and HORIBA will continue validation efforts as they work toward practical deployment of the system in commercial biopharmaceutical manufacturing.
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