Genomenon Teams with Compass for Genomic Innovation

Genomenon, a leading genomic intelligence company, has announced a strategic partnership with Compass Bioinformatics to integrate Genomenon’s Mastermind FLEX Data into Compass Bioinformatics’ InheriNext platform for genetic disease diagnostics. Mastermind FLEX is a comprehensive dataset that combines expertly curated gene and variant-level information with indexed variant content, designed to accelerate precision in genomic interpretation.

The collaboration brings together Compass Bioinformatics’ AI-powered genomic analysis and Genomenon’s evidence-based genomic intelligence to strengthen variant interpretation for clinicians and researchers worldwide. The partnership enhances InheriNext for U.S. users while driving broader adoption of Mastermind in Japan, expanding Genomenon’s presence in Asia and reinforcing its position as a gold standard for genomic evidence.

InheriNext, a rapidly growing web-based genetic analysis platform, has already been adopted this year by more than 40 leading rare disease research and diagnostic institutes in Japan. With over 10,000 cases analyzed at top medical centers, it has become a trusted solution for variant analysis and interpretation. Through the integration of Mastermind FLEX Data, InheriNext users gain access to the world’s most comprehensive and continuously updated genomic literature database, including expertly curated variant data aligned with ACMG guidelines.

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This integration provides clinicians with robust supporting evidence for pathogenic variant interpretation, streamlines manual review processes, and enhances confidence in clinical decision-making. It also enables the reanalysis of unsolved cases as new discoveries emerge. Variants previously classified as VUS (Variant of Uncertain Significance) may now be reinterpreted with confidence, offering undiagnosed patients new possibilities for answers.

InheriNext already delivers automated, accurate, and efficient genomic analysis through phenotype-based ranking, family-based analysis, domain-specific AI algorithms, and integrated reporting tools. By incorporating Genomenon’s Mastermind FLEX Data, the platform now ensures that every variant interpretation is backed by the most comprehensive, literature-based evidence available, ultimately improving diagnostic outcomes and advancing the field of genomic medicine.