{"id":39723,"date":"2026-09-30T12:16:08","date_gmt":"2026-09-30T12:16:08","guid":{"rendered":"https:\/\/itbusinesstoday.com\/?p=39723"},"modified":"2026-09-30T12:16:08","modified_gmt":"2026-09-30T12:16:08","slug":"sola-biosciences-japan-secures-%c2%a56b-grant-for-als-gene-therapy","status":"publish","type":"post","link":"https:\/\/itbusinesstoday.com\/ja\/health-tech\/pharma\/sola-biosciences-japan-secures-%c2%a56b-grant-for-als-gene-therapy\/","title":{"rendered":"SOLA Biosciences Japan\u3001ALS\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u5411\u305160\u5104\u5186\u306e\u52a9\u6210\u91d1\u3092\u78ba\u4fdd\u3057\u305f"},"content":{"rendered":"

\u30dc\u30b9\u30c8\u30f3\u306b\u672c\u793e\u3092\u7f6e\u304fSOLA Biosciences Inc.\u306e\u65e5\u672c\u6cd5\u4eba\u3067\u3042\u308bSOLA Biosciences Japan GK\u306f\u3001AMED\uff08\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff09\u304b\u3089\u7d0460\u5104\u5186\u306e\u652f\u63f4\u3092\u53d7\u3051\u305f\u3002\u3053\u306e\u8cc7\u91d1\u306f\u3001\u540c\u793e\u306e\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u63a8\u9032\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002.<\/p>

\u3053\u306e\u8cc7\u91d1\u306f\u3001\u4eca\u5f8c5\u5e74\u9593\u306b\u308f\u305f\u308a\u300cSOL-257\u300d\u3068\u547c\u3070\u308c\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u652f\u63f4\u3059\u308b\u3082\u306e\u3060\u3002\u3053\u308c\u306f\u3001AMED\u306e\u300c\u533b\u85ac\u54c1\u30b9\u30bf\u30fc\u30c8\u30a2\u30c3\u30d7\u30fb\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u5f37\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\u300d\u306e\u4e00\u74b0\u3067\u3042\u308b\u3002 AMED\u306f\u3001ALS\u306e\u9032\u884c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3001\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305fTDP-43\u3092\u6a19\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u958b\u767a\u30d1\u30fc\u30c8\u30ca\u30fc\u3068\u3057\u3066\u3001SOLA Biosciences Japan\u3092\u9078\u5b9a\u3057\u305f\u3002.<\/p>

\u3053\u306e\u52a9\u6210\u91d1\u306b\u3088\u308a\u3001SOLA Japan\u306f\u540c\u793e\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u4e8b\u696d\u306e\u4e2d\u6838\u3068\u306a\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7c73\u56fd\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u3068\u65e5\u672c\u304a\u3088\u3073\u4e16\u754c\u4e2d\u306e\u6a5f\u95a2\u3068\u306e\u9023\u643a\u304c\u4fc3\u9032\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u958b\u767a\u30b0\u30eb\u30fc\u30d7\u3001\u88fd\u9020\u30d1\u30fc\u30c8\u30ca\u30fc\u3001\u6295\u8cc7\u5bb6\u3068\u306e\u9023\u643a\u3082\u56f3\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3002.<\/p>

SOL-257\u306f\u3001\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305fTDP-43\u3092\u6a19\u7684\u3068\u3059\u308b<\/h3>

SOL-257\u306f\u3001ALS\u60a3\u8005\u306e\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u84c4\u7a4d\u3059\u308bTDP-43\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002 SOLA\u306b\u3088\u308b\u3068\u3001ALS\u60a3\u8005\u306e97%\u306b\u304a\u3044\u3066\u3001TDP-43\u306e\u5c40\u5728\u7570\u5e38\u3001\u8aa4\u6298\u308a\u7573\u307f\u3001\u51dd\u96c6\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u305f\u3081\u3001TDP-43\u306f\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u304a\u3051\u308b\u6975\u3081\u3066\u91cd\u8981\u306a\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u308b\u3002.<\/p>

\u5358\u306a\u308b\u75c7\u72b6\u306e\u7ba1\u7406\u306b\u3068\u3069\u307e\u3089\u305a\u3001SOLA\u306f\u6839\u672c\u539f\u56e0\u3067\u3042\u308b\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4fee\u6b63\u3059\u308b\u305f\u3081\u3001SOL-257\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002\u305d\u306e\u76ee\u7684\u306f\u3001\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305fTDP-43\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u3060\u3002\u3053\u308c\u304c\u6210\u529f\u3059\u308c\u3070\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u640d\u50b7\u3092\u9045\u3089\u305b\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u98df\u3044\u6b62\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3060\u308d\u3046\u3002.<\/p>

\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u307e\u3060\u958b\u767a\u6bb5\u968e\u306b\u3042\u308b\u3002\u307e\u3060\u627f\u8a8d\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u4eba\u306b\u5bfe\u3057\u3066\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306b\u4f5c\u7528\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3060\u3002.<\/p>

JUMP70\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u7ba1\u7406\u3092\u6d3b\u7528\u3057\u3066\u3044\u308b<\/h3>

SOL-257\u306f\u3001SOLA\u304c\u72ec\u81ea\u306b\u958b\u767a\u3057\u305fJUMP70\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u7528\u3044\u3066\u958b\u767a\u3055\u308c\u305f\u3002\u3053\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u7570\u5e38\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9078\u629e\u7684\u306b\u8a8d\u8b58\u3057\u3064\u3064\u3001\u6b63\u5e38\u306b\u6a5f\u80fd\u3059\u308b\u305d\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u305d\u306e\u307e\u307e\u6b8b\u3059\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>

\u3053\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u75be\u60a3\u7279\u7570\u7684\u306a\u6a19\u7684\u5316\u8981\u7d20\u3068\u3001\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u54c1\u8cea\u7ba1\u7406\u30b7\u30b9\u30c6\u30e0\u3092\u6d3b\u6027\u5316\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u305f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u305f\u305f\u307f\u3084\u54c1\u8cea\u7ba1\u7406\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3067\u3042\u308bHSP70\u3092\u3001\u6a19\u7684\u3068\u306a\u308b\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u3068\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3042\u308b\u3002.<\/p>

SOL-257\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u306e\u6280\u8853\u306f\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305fTDP-43\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u3002SOLA\u306b\u3088\u308b\u3068\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u5358\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9664\u53bb\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6b63\u5e38\u306aTDP-43\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u306e\u56de\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002.<\/p>

\u540c\u793e\u306e\u3088\u308a\u5e83\u7bc4\u306a\u300cJUMP70\u300d\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306b\u306f\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u95a2\u9023\u3059\u308b\u8aa4\u6298\u308a\u7573\u307f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u3082\u542b\u307e\u308c\u3066\u3044\u308b\u3002.<\/p>

\u65e5\u672c\u304c\u91cd\u8981\u306a\u958b\u767a\u62e0\u70b9\u3068\u306a\u308b<\/h3>

AMED\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3088\u308a\u3001SOLA\u306f\u7c73\u56fd\u4f01\u696d\u767a\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u3001\u65e5\u672c\u3092\u62e0\u70b9\u3068\u3059\u308b\u958b\u767a\u4f53\u5236\u3092\u69cb\u7bc9\u3059\u308b\u6a5f\u4f1a\u3092\u5f97\u305f\u3002.<\/p>

SOLA Biosciences Japan\u306f\u3001\u7c73\u56fd\u306e\u30c1\u30fc\u30e0\u3068\u9023\u643a\u3057\u3001\u56fd\u5185\u5916\u306e\u7814\u7a76\u6a5f\u95a2\u3001\u81e8\u5e8a\u6a5f\u95a2\u3001\u88fd\u9020\u30d1\u30fc\u30c8\u30ca\u30fc\u3068\u5354\u529b\u3057\u3066\u3044\u304f\u8a08\u753b\u3060\u3002Curie.Bio\u304c\u30ea\u30fc\u30c9\u6295\u8cc7\u5bb6\u3068\u3057\u3066\u53c2\u52a0\u3057\u3001\u6771\u4eac\u5927\u5b66\u30a8\u30c3\u30b8\u30fb\u30ad\u30e3\u30d4\u30bf\u30eb\u30fb\u30d1\u30fc\u30c8\u30ca\u30fc\u30ba\uff08UTEC\uff09\u304c\u30d5\u30a9\u30ed\u30fc\u30aa\u30f3\u6295\u8cc7\u5bb6\u3068\u3057\u3066\u53c2\u52a0\u3057\u3066\u3044\u308b\u3002.<\/p>

\u65e5\u672c\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u5206\u91ce\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u53d6\u308a\u6c7a\u3081\u306f\u3001\u653f\u5e9c\u4e3b\u5c0e\u306e\u8cc7\u91d1\u63d0\u4f9b\u304c\u3001\u6d77\u5916\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3068\u56fd\u5185\u306e\u7814\u7a76\u30fb\u81e8\u5e8a\u30fb\u88fd\u9020\u80fd\u529b\u3068\u3092\u7d50\u3073\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002.<\/p>

AMED\u306e\u516c\u5f0f\u767a\u8868\u306b\u3088\u308b\u3068\u3001SOLA Japan\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u7570\u5e38\u6298\u308a\u305f\u305f\u307e\u308c\u305fTDP-43\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u907a\u4f1d\u5b50\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304a\u3088\u3073\u5546\u696d\u5316\u3067\u3042\u308b\u3002\u540c\u6a5f\u95a2\u306f\u5be9\u67fb\u30d7\u30ed\u30bb\u30b9\u3092\u7d4c\u3066\u300110\u4ef6\u306e\u7533\u8acb\u306e\u4e2d\u304b\u3089\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u9078\u5b9a\u3057\u305f\u3002.<\/p>

\u4eba\u9593\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6982\u5ff5\u5b9f\u8a3c\u306b\u5411\u3051\u3066<\/h3>

\u3053\u3061\u3089\u3082\u304a\u8aad\u307f\u304f\u3060\u3055\u3044\uff1a ITM\u3068Lumara Bio\u3001ITM-11\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u60c5\u5831\u3092\u516c\u8868\u3057\u305f<\/a><\/h4>

\u3053\u306e5\u30ab\u5e74\u8a08\u753b\u306e\u4e0b\u3001SOLA\u306f\u3001SOL-257\u306b\u3064\u3044\u3066\u65e5\u672c\u304a\u3088\u3073\u7c73\u56fd\u53cc\u65b9\u3067\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6982\u5ff5\u5b9f\u8a3c\uff08PoC\uff09\u3078\u3068\u9032\u3081\u3001\u305d\u306e\u5f8c\u306e\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u81e8\u5e8a\u958b\u767a\u306b\u5411\u3051\u305f\u57fa\u76e4\u3092\u7bc9\u304f\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002.<\/p>

\u3053\u306e\u8cc7\u91d1\u63d0\u4f9b\u3060\u3051\u3067\u306f\u3001SOL-257\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3084\u5546\u696d\u7684\u5b9f\u73fe\u53ef\u80fd\u6027\u304c\u7acb\u8a3c\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002ALS\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3092\u5224\u65ad\u3059\u308b\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u958b\u767a\u3001\u81e8\u5e8a\u8a66\u9a13\u3001\u304a\u3088\u3073\u898f\u5236\u5f53\u5c40\u306b\u3088\u308b\u8a55\u4fa1\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002.<\/p>

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SOLA Biosciences Japan GK, the branch of the Boston-based company SOLA Biosciences Inc. has received about ¥6 billion in support from the Japan Agency for Medical Research and Development known as AMED. This funding is meant to help advance the company’s gene therapy program for lateral sclerosis or ALS.The money will support the development of a treatment called SOL-257 over the five years. It is part of AMED’s Strengthening Program for Pharmaceutical Startup Ecosystem. AMED chose SOLA Biosciences Japan as the development partner for a gene therapy that targets misfolded TDP-43, a protein that plays a key role in the progression of ALS.This grant puts SOLA Japan at the heart […]<\/p>\n","protected":false},"author":7,"featured_media":39745,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"wprm-recipe-roundup-name":"","wprm-recipe-roundup-description":"","postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""},"footnotes":""},"categories":[89,8098,182],"tags":[11744,314,12813,575,16012],"ppma_author":[572],"class_list":["post-39723","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health-tech","category-news-articles","category-pharma","tag-gene-therapy","tag-japan","tag-medical-research","tag-pharmaceutical","tag-sola-biosciences"],"yoast_head":"\nSOLA Biosciences Japan Lands \u00a56B for ALS Research<\/title>\n<meta name=\"description\" content=\"SOLA Biosciences Japan receives a \u00a56 billion grant to advance research and development of an ALS gene therapy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/itbusinesstoday.com\/ja\/health-tech\/pharma\/sola-biosciences-japan-secures-\u00a56b-grant-for-als-gene-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SOLA Biosciences Japan Lands \u00a56B for ALS Research\" \/>\n<meta property=\"og:description\" content=\"SOLA Biosciences Japan receives a \u00a56 billion grant to advance research and development of an ALS gene therapy.\" \/>\n<meta property=\"og:url\" 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